Description
A steroid saponin with anticancer activity; inhibits the proliferation of HepG2 and HepG2/ADR cells at 1.98 and 2.97 µM; reduces ADR resistance in HepG2/ADR cells when administered in combination with ADR, an effect that is enhanced by addition of LY294002 and SB203580; inhibits the proliferation of MDA-MB-231, MDA-MB-436, and MCF-7 breast cancer cells (IC50s = 3.16, 3.45, and 2.86 µM, respectively); induces intratumoral autophagy and reduces tumor growth in an MDA-MB-231 mouse xenograft model at 1.5 mg/kg